Past papers: 2005

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Below are a number of refereed papers from 2005 in which Perceptive Instruments software is used for the comet assay. Applications of the systems include research and testing in nutrition, medicine, biomonitoring and genetic toxicology:

Biocompatibility In Vitro Tests of Mineral Trioxide Aggregate and Regular and White Portland Cements
(2005) D.A. Ribeiro et al, Journal of Endodontics 31(8):605-607

The novel human gene aprataxin is directly involved in DNA single-strand-break repair
(2005) P. Mosesso et al, Cellular and Molecular Life Sciences 62(4):485-491

Genetic polymorphisms and the effect of cigarette smoking in the comet assay
(2005) H. Hoffmann et al, Mutagenesis 20(5):359-364

The green tea polyphenol (-)-epigallocatechin gallate and green tea can protect human cellular DNA from ultraviolet and visible radiation-induced damage
(2005) N. Morley et al, Photodermatology, Photoimmunology & Photomedicine 21(1):15-22

Radiosensitivity of lymphoblastoid cell lines with a heterozygous BRCA1 mutation is not detected by the comet assay and pulsed field gel electrophoresis
(2005) K. Trenz, P. Schütz and G. Speit, Mutagenesis 20(2):131-137

Effects of pesticides on human peripheral lymphocytes in vitro: induction of DNA damage
(2005) Ü. Ündeger and N. Basaran, Archives of Toxicology 79(3):169-176

Assessment of genetic damage induced by dental bleaching agents on mouse lymphoma cells by single cell gel (comet) assay
(2005) D.A. Ribeiro, M.E.A. Marques and D.M.F. Salvadori, Journal of Oral Rehabilitation 32(10):766–771

Investigation into possible DNA damaging effects of ultrasound in occupationally exposed medical personnel - the alkaline comet assay study
(2005) V. Garaj-Vrhovac and N. Kopjar, Journal of Applied Toxicology 25(3):184-192

In vitro biocompatibility tests of two commercial types of mineral trioxide aggregate
(2005) D.A. Ribeiro et al, Brazilian Oral Research 19(3):183-187

Involvement of oxygen free radicals in the serum-mediated increase of benzoquinone genotoxicity
(2005) R. Fabiani, A. De Bartolomeo and G. Morozzi, Environmental and Molecular Mutagenesis 46(3):156-163

Transcription-Associated Breaks in Xeroderma Pigmentosum Group D Cells from Patients with Combined Features of Xeroderma Pigmentosum and Cockayne Syndrome
(2005) T. Theron et al, Molecular and Cellular Biology 25(18):8368-8378

Rehabilitation Decreases Exercise-induced Oxidative Stress in Chronic Obstructive Pulmonary Disease
(2005) E.M. Mercken et al, American Journal of Respiratory and Critical Care Medicine 172:994-1001

Nitrite enhances neutrophil-induced DNA strand breakage in pulmonary epithelial cells by inhibition of myeloperoxidase
(2005) A.M. Knaapen et al, Carcinogenesis 26(9):1642-1648

Metal-specific differences in levels of DNA damage caused by synovial fluid recovered at revision arthroplasty
(2005) A.P. Davies et al, Journal of Bone and Joint Surgery 87-B(10):1439-1444

Inhibition of cell growth and induction of apoptosis in human prostate cancer cell lines by 6-aminoquinolone WM13
(2005) A. Minelli et al, Oncology reports 13(6):1113-20

DNA damage and G2/M arrest in Syrian hamster embryo cells during Malachite green exposure are associated with elevated phosphorylation of ERK1 and JNK1
(2005) B. Bose, L. Motiwale, K. Rao, Cancer Letters 230(2):260-270

Dose – response for radiation-induced apoptosis, residual 53BP1 foci and DNA-loop relaxation in human lymphocytes
(2005) J.Torudd et al, International Journal of Radiation Biology 81(2):125-138

Single and repeated moderate consumption of native or dealcoholized red wine show different effects on antioxidant parameters in blood and DNA strand breaks in peripheral leukocytes in healthy volunteers: a randomized controlled trial
(2005) B.M. Arendt et al, Nutrition Journal 4(33)

Ochratoxin A induces oxidative DNA damage in liver and kidney after oral dosing to rats
(2005) H.G. Kamp et al, Molecular Nutrition & Food Research 49(12):1160-1167

Chromatin supraorganization, DNA fragmentation, and cell death in snake erythrocytes.
(2005) M. Miyamoto et al, Biochemistry and cell biology 83(1):15-27

Modulation of endothelial and smooth muscle function by bed rest and hypoenergetic, low-fat nutrition
(2005) C. Hesse et al, Journal of Applied Physiology 99:2196-2203

Genotoxicity of 4-Hydroxy-2-Nonenal in Human Colon Tumor Cells Is Associated with Cellular Levels of Glutathione and the Modulation of Glutathione S-Transferase A4 Expression by Butyrate
(2005) N. Knoll et al, Toxicological Sciences 86(1):27-35

Polyphenolic apple juice extracts and their major constituents reduce oxidative damage in human colon cell lines
(2005) S.Schaefer et al, Molecular Nutrition & Food Research 50(1):24-33

Cloudy apple juice decreases DNA damage, hyperproliferation and aberrant crypt foci development in the distal colon of DMH-initiated rats
(2005) S.W. Barth et al, Carcinogenesis 26(8):1414-1421