Past papers: 2006

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Below are a number of refereed papers from 2006 in which Perceptive Instruments software is used for the comet assay. Applications of the systems include genotoxicity testing of materials used in dentistry; potentially harmful and beneficial dietary factors; biomonitoring; molecular epidemiology; photobiology; mechanistic studies and clinical.

Genotoxicity and cytotoxicity of mineral trioxide aggregate and regular and white Portland cements on Chinese hamster ovary (CHO) cells in vitro
(2006) D. Ribeiro et al, Oral Surg. 101(2):258-261

DNA damage in multiple organs after exposure to chlorhexidine in Wistar rats
(2006) T.F. Grassi et al, 210(2):163-167

In vitro cytotoxic and non-genotoxic effects of gutta-percha solvents on mouse lymphoma cells by single cell gel (comet) assay
(2006) D.A. Ribiero et al, Braz. Dent. J. 17(3)

Effects of co-exposure to extremely low frequency (50 Hz) magnetic fields and xenobiotics determined in vitro by the alkaline comet assay
(2006) M. Villarini et al, Sci. Total Env. 361(1-3):208-219

The neutral diffusion assay as an estimate of cytotoxicity in the comet assay
(2006) C.Rider et al, Toxicology 226(1):58-59

Standard and Fpg-modified comet assay in kidney cells of ochratoxin A- and fumonisin B1-treated rats
(2006) A.Domijan et al, Toxicology 222(1-2):53-59

Alkaline comet assay study with breast cancer patients: evaluation of baseline and chemotherapy-induced DNA damage in non-target cells
(2006) N. Kopjar et al, Clin. Exp. Med. 6(4):177-190

Photo-chemically induced DNA effects in the comet assay with epidermal cells of SKH-1 mice after a single oral administration of different fluoroquinolones and 8-methoxypsoralen in combination with exposure to UVA
(2006) U.Wirnitzer et al, Mut. Res. 609(1):1-10

DNA damage and repair capacity by comet assay in lymphocytes of white-collar active smokers and passive smokers (non- and ex-smokers) at workplace
(2006) M. Fracasso et al, Toxicology Let. 167(2):131-141

Genotoxicity in primary human peripheral lymphocytes after exposure to regular and white mineral trioxide aggregate
(2006) G. da Silva et al, Oral Surg. 102(5):e50-e54

Antimicrobial endodontic compounds do not modulate alkylation-induced genotoxicity and oxidative stress in vitro
(2006) D.A. Ribeiro et al, Oral Surg. 102(2):e32-e36

Biocompatibility of glass–ionomer cements using mouse lymphoma cells in vitro
(2006) D.A. Ribeiro et al, Oral Rehab. 33(12):912-917

Antioxidant and antigenotoxic activities of Angelica keiskei, Oenanthe javanica and Brassica oleracea in the Salmonella mutagenicity assay and in HCT116 human colon cancer cells
(2006) D. Kwon et al, BioFactors 26(4):231-244

Investigation of cytotoxic, genotoxic, mutagenic, and estrogenic effects of the flame retardants tris-(2-chloroethyl)-phosphate (TCEP) and tris-(2-chloropropyl)-phosphate (TCPP) in vitro
(2006) W. Föllmann and J. Wober, Toxicology Let.161(2):124-134

Oxidative stress as DNA damage in different transgenic tobacco plants
(2006) A. Mancini et al, Plant Sci. 170(7):845-852

Glutathione S-transferase polymorphisms and ochratoxin A toxicity in primary human urothelial cells
(2006) S. Lebrun et al, Toxicology 224(1-2):81-90

2-Dodecylcyclobutanone, a radiolytic product of palmitic acid, is genotoxic in primary human colon cells and in cells from preneoplastic lesions
(2006) N. Knoll et al, Mut. Res. 594(1-2):10-19

Genotoxic effects of myosmine in a human esophageal adenocarcinoma cell line
(2006) S. Vogt, K. Fuchs and E. Richter, Toxicology 222(1):71-79

Effects of quercetin on ß-apo-8'-carotenal-induced DNA damage and cytochrome P1A2 expression in A549 cells
(2006) S. Yeh and S. Wu, Chem-Bio. Int. 163(3):199-206

The hollow fibre model - facilitating anti-cancer pre-clinical pharmacodynamics and improving animal welfare
(2006) M. Suggitt et al, Int. J Oncol. 29(6):1493-1499

Influence of the SCGE protocol on the amount of basal DNA damage detected in the Mediterranean mussel, Mytilus galloprovincialis
(2006) N. Machella et al, Env. Mol. Mutagen 47(8):579-586

Multifunctional polyvinylpyrrolidinone-polyacrylic acid copolymer hydrogels for biomedical applications
(2006) D. M. Devine et al, Int. J Pharma. 326(1-2):50-59

Influence of biotransformation on trophic transfer of the PAH, fluoranthene
(2006) A.Palmqvist et al, Aqua. Tox. 80(3):309-319

Mutagenicity of cytochrome P450 2E1 substrates in the Ames test with the metabolic competent S. typhimurium strain YG7108pin3ERb₅
(2006) B.Emmert et al, Toxicology 228(1):66-76

A Protease Pathway for the Repair of Topoisomerase II-DNA Covalent Complexes
(2006) A. Zhang et al, Journal of Biological Chemistry 281(47):35997-36003

Hg(II) Exposure Exacerbates UV-Induced DNA Damage in MRC5 Fibroblasts: A Comet Assay Study
(2006) W. Bradfield et al, Journal of Environmental Science and Health Part A 41(2):143-148

Lack of DNA damage induced by fluoride on mouse lymphoma and human fibroblast cells by single cell gel (comet) assay
(2006) D.A. Ribeiro et al, Brazilian Dental Journal 17(2):91-94

DNA damage by ochratoxin A in rat kidney assessed by the alkaline comet assay
(2006) D. Želježic et al, Braz J Med Biol Res [online]

Development and validation of a modified comet assay to phenotypically assess nucleotide excision repair
(2006) S. Langie et al, Mutagenesis 21(2):153-158

Evaluation of DNA damage in white blood cells of healthy human volunteers using the alkaline comet assay and the chromosome aberration test
(2006) N. Kopjar, D. Zeljezic and V. Garaj-Vrhovac, Acta biochimica Polonica 53(2):321-336

hOGG1 recognizes oxidative damage using the comet assay with greater specificity than FPG or ENDOIII
(2006) C.Smith, M.O'Donovan and E.Martin, Mutagenesis 21(3):185-190

Ex vivo biocompatibility tests of regular and white forms of mineral trioxide aggregate
(2006) D.A. Ribeiro et al, International Endodontic Journal 39(1):26-30

Genotoxicity and cytotoxicity of glass ionomer cements on Chinese hamster ovary (CHO) cells
(2006) D.A. Ribeiro et al, Journal of Materials Science: Materials in Medicine 17(6):495-500

Study of DNA damage induced by dental bleaching agents in vitro
(2006) D.A. Ribeiro et al, Brazilian Oral Research 20(1):47-51

The protective effect of L-carnitine in peripheral blood human lymphocytes exposed to oxidative agents
(2006) C.L. Garcia et al, Mutagenesis 21(1):21-27

Evaluation of genetic damage in human peripheral lymphocytes exposed to mineral trioxide aggregate and Portland cements
(2006) M.G. Braz et al, Journal of Oral Rehabilitation 33(3):234-239

The Parp-1 Inhibitor INO-1001 Facilitates Hemodynamic Stabilization Without Affecting DNA Repair in Porcine Thoracic Aortic Cross-Clamping-Induced Ischemia/Reperfusion
(2006) B. Hauser et al, Shock 25(6):633-640

DNA repair contributes to the drug-resistant phenotype of primary acute myeloid leukaemia cells with FLT3 internal tandem duplications and is reversed by the FLT3 inhibitor PKC412
(2006) C. Seedhouse et al, Leukemia 20:2130–2136

Modulation of oxidative cell damage by reconstituted mixtures of phenolic apple juice extracts in human colon cell lines
(2006) S. Schaefer, M. Baum, G. Eisenbrand and C. Janzowski, Molecular Nutrition and Food Research 50(4-5):413-417

Dithiol Compounds at Low Concentrations Increase Arsenite Toxicity
(2006) K.Y. Jan et al, Toxicological Sciences 90(2):432-439

Hemoglobin and hemin induce DNA damage in human colon tumor cells HT29 clone 19A and in primary human colonocytes
(2006) M. Glei et al, Toxicological Sciences 90(2):432-439