Past papers: 2007

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Below are a number of refereed papers from 2007 in which Perceptive Instruments software is used for the comet assay. Applications of the systems include potentially harmful and beneficial dietary factors; biomonitoring; molecular epidemiology; photobiology; mechanistic studies, clinical and dentistry.

L-Carnitine enhances resistance to oxidative stress by reducing DNA damage in Ataxia telangiectasia cells
(2007) A. Berni et al, Mut. Res. 650(2):165-174

Discriminative protection against hydroxyl and superoxide anion radicals by quercetin in human leucocytes in vitro
(2007) L.C. Wilms et al, Tox. in Vitro 22(2):301-307

Distinct roles of Topoisomerase II isoforms: DNA damage accelerating greek small letter alpha, double strand break repair promoting ß
(2007) R.K. Madraju et al, Arc. Biochm. & BioPhy. 470(1):27-34

Relationship among Oxidative DNA Damage, Gastric Mucosal Density and the Relevance of cagA , vacA and iceA Genotypes of Helicobacter pylori
(2007) M.S.P Ladeira et al, Digestive Dis. & Sci. 53(1):248-255

Antigenotoxicity and antimutagenicity of lycopene in HepG2 cell line evaluated by the comet assay and micronucleus test
(2007) C.Scolasti et al, Tox. in Vitro 22(2):510-514

Nanoparticle-driven DNA damage mimics irradiation-related carcinogenesis pathway
(2007) R.M. Mroz et al, Eur Respir J 31(1):241-251

Genotoxicity of tryptophol in a battery of short-term assays on human white blood cells in vitro.
(2007) I. Kosalec et al, Basic Clin. Pharma. Tox. 102(5):443-452

Genotoxicity in primary human peripheral lymphocytes after exposure to radiopacifiers in vitro
(2007) M. Gobbo Braz et al, Materials in Med. 19(2):601-605

Essential Roles for Fe65, Alzheimer Amyloid Precursor-binding Protein, in the Cellular Response to DNA Damage
(2007) G. Minopoli et al, J. Biol. Chem. 282(2):831-835

DNA damage in multiple organs after exposure to chlorhexidine in Wistar rats
(2007) T. Grassi et al, Int. J. Hygiene & Env. Health 210(2):163-167

The quercetin paradox
(2007) A.W. Boots et al, Tox & Appl. Pharma. 222(1):89-96

Genotoxic effects induced by formaldehyde in human blood and implications for the interpretation of biomonitoring studies
(2007) O. Schmid and G. Speit, Mutagenesis 22(1):69-74

Use of sensitive methods for detection of DNA damage on human lymphocytes exposed to p,p'-DDT: Comet assay and new criteria for scoring micronucleus test
(2007) G. Gajski et al, J. Env. Sci & Health Pt.B 42(6):607-613

Chicken nucleated blood cells as a cellular model for genotoxicity testing using the comet assay
(2007) M. Sokolovic et al, Food & Chem. Tox. 45(11):2165-2170

Influence of endogenous and synthetic female sex hormones on human blood cells in vitro studied with comet assay
(2007) M. Gobbo Braz and D. M. Fávero Salvadori, Tox. in Vitro 21(5):972-976

DNA-damaging ability of isoprene and isoprene mono-epoxide (EPOX I) in human cells evaluated with the comet assay
(2007) R. Fabiani et al, Mut. Res. 629(1):7-13

Genetic damage in human peripheral lymphocytes exposed to antimicrobial endodontic agents
(2007) G. N. Da Silva et al, Oral Surg. 104(2):e58-e61

Genotoxic effects of exposure to radiofrequency electromagnetic fields (RF-EMF) in cultured mammalian cells are not independently reproducible
(2007) G. Speit et al, Mut. Res. 622(1-2):42-47

Biocompatibility of gutta-percha solvents using in vitro mammalian test-system
(2007) D. Ribeiro et al, Oral Surg. 103(5):e106-e109

Absence of DNA damage in multiple organs (blood, liver, kidney, thyroid gland and urinary bladder) after acute fluoride exposure in rats
(2007) A. de Lima Leite et al, Human & Expt. Tox. 26(5):435-440

Genotoxic effects in the Eastern mudminnow (Umbra pygmaea L.) after exposure to Rhine water, as assessed by use of the SCE and Comet assays: A comparison between 1978 and 2005
(2007) G. M. Alink et al, Mut. Res. 631(2):93-100

Evaluation of level of DNA damage in blood leukocytes of non-diabetic and diabetic rat exposed to cigarette smoke
(2007) P. H. Ortiz Lima et al, Mut. Res. 628(2):117-122

GSTM1 and GSTT1 polymorphism influences protection against induced oxidative DNA damage by quercetin and ascorbic acid in human lymphocytes in vitro
(2007) L. C. Wilms et al, Food & Chem. Tox. 45(12):2592-2596

Lycopene activity against chemically induced DNA damage in Chinese hamster ovary cells
(2007) C. Scolastici et al, Tox. in Vitro 21(5):840-845

DNA damage and nitric oxide synthesis in experimentally infected Balb/c mice with Trypanosoma cruzi
(2007) D. Ribeiro et al, Expt. Parasitology. 116(3):296-301

Differential response related to genotoxicity between eggplant (Solanum melanogena) skin aqueous extract and its main purified anthocyanin (delphinidin) in vivo
(2007) L. Azevedo et al, Food & Chem. Tox. 45(5):852-858

Fumonisin B1: Oxidative status and DNA damage in rats
(2007) A. Domijan et al, Toxicology 232(3):163-169

Characterization of the genotoxic potential of formaldehyde in V79 cells
(2007) G. Speit et al, Mutagenesis 22(6):387-394

8-Oxoguanine DNA Glycosylase and MutY Homolog Are Involved in the Incision of Arsenite-Induced DNA Adducts
(2007) Y. Pu et al, Tox. Sci. 95(2):376-382

In vitro cytotoxicity and genotoxicity of chlorinated drinking waters sampled along the distribution system of two municipal networks
(2007) L. Marabini et al, Mut. Res. 634(1-2):1-13

Comparative evaluation of acetylcholinesterase status and genome damage in blood cells of industrial workers exposed to carbofuran
(2007) D. Zeljezic et al, Food and Chem. Tox. 45(12):2488-2498

Primary DNA damage and genetic polymorphisms for CYP1A1, EPHX and GSTM1 in workers at a graphite electrode manufacturing plant
(2007) M. Moretti et al, BMC Pub. Health 7:270

Impact of multiple genetic polymorphisms on effects of a 4-week blueberry juice intervention on ex vivo induced lymphocytic DNA damage in human volunteers
(2007) L. C. Wilms et al, Carcinogenesis 28(8):1800-1806

An optimized method for detecting gamma-H2AX in blood cells reveals a significant interindividual variation in the gamma-H2AX response among humans
(2007) I. H. Ismail et al, Nuc. Acids Res. 35(5):e36

TDP1 facilitates repair of ionizing radiation-induced DNA single-strand breaks
(2007) S. F. El-Khamisy et al, DNA Repair 6(10):1485-1495

Irinotecan Toxicity to Human Blood Cells in vitro: Relationship between Various Biomarkers
(2007) N. Kopjar et al, Bas. Clin. Pharma. & Tox. 100(6):403-413

Inhibition of the mitochondrial respiratory chain function abrogates quartz induced DNA damage in lung epithelial cells
(2007) H. Li et al, Mut. Res. 617(1-2):46-57

Poly(ADP-Ribose) Polymerase 1 Accelerates Single-Strand Break Repair in Concert with Poly(ADP-Ribose) Glycohydrolase
(2007) A. E. O. Fisher et al, Mol. Cell. Biol. 27(11):5597-5605

Blood mononucleocytes are sensitive to the DNA damaging effects of iron overload—In vitro and ex vivo results with human and rat cells
(2007) E. Park et al, Mut. Res. 619(1-2):59-67

Dietary synbiotics reduce cancer risk factors in polypectomized and colon cancer patients
(2007) J. Rafter et al, Amer. J. Clin. Nutr. 85(2):488-496

The effect of nano- and micron-sized particles of cobalt–chromium alloy on human fibroblasts in vitro
(2007) I. Papageorgiou et al, Biomaterials 28(19):2946-2958

Fecal Water as a Non-Invasive Biomarker in Nutritional Intervention: Comparison of Preparation Methods and Refinement of Different Endpoints
(2007) A. Klinder et al, Nut. & Cancer 57(2):158-167

Toxicological potential of 2-alkylcyclobutanones – specific radiolytic products in irradiated fat-containing food – in bacteria and human cell lines
(2007) A. Hartwig et al, Food & Chem. Tox. 45(12):2581-2591

Human gastric cells resistant to (-)-epigallocatechin gallate show cross-resistance to several environmental pollutants
(2007) S.B. Horng et al, Food & Chem. Tox. 45(11):2171-2178

Genotoxic effects of particles of surgical cobalt chrome alloy on human cells of different age in vitro
(2007) I. Papageorgiou et al, Mut. Res. 619(1-2):45-58

TDP1 facilitates chromosomal single-strand break repair in neurons and is neuroprotective in vivo
(2007) S. Katyal et al, EMBO J. 26:4720-4731

DNA damage, acetylcholinesterase activity and lysosomal stability in native and transplanted mussels (Mytilus edulis) in areas close to coastal chemical dumping sites in Denmark
(2007) J. Rank et al, Aqua. Tox. 84(1):50-61

The environmental carcinogen 3-nitrobenzanthrone and its main metabolite 3-aminobenzanthrone enhance formation of reactive oxygen intermediates in human A549 lung epithelial cells
(2007) T. Hansen et al, Tox. & App. Pharma. 221(2):222-234

Genotoxicity of Corrosion Eluates Obtained From Endosseous Implants
(2007) D. Ribeiro et al, Implant Dent. 16(1):101-109