A long history of collaboration and a strong future in the application of 3D models for genotoxicity assessment
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- Created: Wednesday, 05 December 2018 14:15
A mini case study from the Department of Genetic Toxicology and Cancer Biology, National Institute of Biology, Ljubljana, Slovenia.
In 2003, this influential research group released their first comet assay publication incorporating research carried out using Instem’s comet scoring solution. Since then, the comet assay system has been an integral part of their research; they have been using Comet Assay IV on a daily basis, producing high-quality, peer-reviewed, comet-featuring publications every year!
Recently, their scientists have been working on a 3D in vitro cell model for the assessment of genotoxic activity of xenobiotics. Their 3D hepatic cell model has an increased metabolic competence and, using the comet assay, they demonstrated its high sensitivity for detecting genotoxic activity of different types of indirect acting genotoxic compounds. This novel approach is just one example of how Comet Assay IV is pushing forward the frontiers of genetox testing.
“In our laboratory Comet Assay IV is used every day often for more than 12 hours a day! Comet assay is an integral part of our research and Comet Assay IV enables gathering reliable data for our genetox publications” Assist. Prof. Bojana Žegura, PhD