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Comet assay news

HepG2 cells under silver nanoparticle-induced stress - comet assay investigation

 Scientists in Poland have been investigating the adaptation of HepG2 cells to silver nanoparticle-induced stress.  They found that the adaptation is based on the pro-proliferative and anti-apoptotic changes in gene expression. 

Resveratrol & the comet assay

Researchers from the Department of Food Chemistry and Toxicology at the University of Vienna have been exploring whether Resveratrol, a naturally occurring polyphenol, modulates the topoisomerase inhibitory potential of doxorubicin in a human cell line.

DNA damage & formaldehyde exposure

Formaldehyde is a commonly used chemical in anatomy and pathology laboratories as a tissue preservative and fixative.  Researchers from Portugal and Spain have been investigating occupational exposure to formaldehyde using the comet assay.

Comet Assay IV & JaCVAM study

The JaCVAM comet assay validation exercise was completed in 2014, resulting in the publication of the comet assay OECD Guideline. Publications have been released that document the use of Comet Assay IV as part of the successful validation process.

Medium-throughput comet assay

Researchers have presented a methods paper describing “a medium-throughput comet assay to evaluate the global DNA methylation status of single cells”.  The versatility of the comet assay allows introduction of various modifications to the basic technique.