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Comet assay news

Reference cells and mixed-ploidy cells in the comet assay

 Scientists at the University of Oslo and Norwegian Institute of Public Health (both based in Oslo, Norway) have been investigating the use of “reference cells” within the comet assay.  They also performed the comet assay on a mixture of testicular cells with various ploidy.

HepG2 cells under silver nanoparticle-induced stress - comet assay investigation

 Scientists in Poland have been investigating the adaptation of HepG2 cells to silver nanoparticle-induced stress.  They found that the adaptation is based on the pro-proliferative and anti-apoptotic changes in gene expression. 

Resveratrol & the comet assay

Researchers from the Department of Food Chemistry and Toxicology at the University of Vienna have been exploring whether Resveratrol, a naturally occurring polyphenol, modulates the topoisomerase inhibitory potential of doxorubicin in a human cell line.

DNA damage & formaldehyde exposure

Formaldehyde is a commonly used chemical in anatomy and pathology laboratories as a tissue preservative and fixative.  Researchers from Portugal and Spain have been investigating occupational exposure to formaldehyde using the comet assay.

Comet Assay IV & JaCVAM study

The JaCVAM comet assay validation exercise was completed in 2014, resulting in the publication of the comet assay OECD Guideline. Publications have been released that document the use of Comet Assay IV as part of the successful validation process.