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Comet assay in cataract research

Cataract development is the leading cause of blindness and visual impairment in the world and the incidence of cataracts continues to increase with the global growing elderly population. Researchers have investigated the mechanisms by which these nutrients provide anti-cataract effects.

Exposure to formaldehyde

Formaldehyde is a global high-production compound with numerous applications ranging from production of resins to medicines. In order to assess the genotoxic effects of chronic occupational exposure to formaldehyde, a group of pathology/anatomy workers were assessed using the comet assay.

Genotoxicity in furnace workers

To investigate the hazard to human DNA in furnace operating workers from a coal fired power station, the Afsin-Elbistan-A Power Plant, Turkey, researchers determined the level of DNA damage in blood samples by measuring comet tail intensity.

DNA damage reduced by pea proteins

Recently, researchers in Thailand reported on the antioxidant potential of biological proteins from pigeon pea seeds. These crude pigeon pea proteins were obtained using an extraction procedure, then incubated with TK6 cells before performing the comet assay.

DNA damage in sea stars

A truly amazing application of the comet assay: investigation into the regeneration of lost body parts in the sea star, Asterias rubens.  Researchers in Sweden and Norway propose a new working hypothesis for arm regeneration in sea stars.