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Low molecular weight DNA diffusion (LMW) and comet assays

 Recently, investigators at Universität Ulm have been investigating the low molecular weight DNA diffusion assay (LMW assay) to measure cytotoxicity in comet assays. Here, the LMW assay has been proposed as an alternative, or a supplementation, to histopathology. 

Risk assessment: comet assay and Pig-a mutation assay used together

The OECD has recently released a test guideline for the in vivo comet assay and, prior to this release, researchers were interested in the performance of a combined comet assay/Pig-a gene mutation study.

OECD Guideline: Test No. 489, In Vivo Mammalian Alkaline Comet Assay

On 26 September 2014, the OECD Council adopted three new, five updated and one corrected OECD Test Guidelines for the testing of chemicals, one of these was Test No. 489, In Vivo Mammalian Alkaline Comet Assay.

Protective properties of coffee

 Researchers across the globe have been using the comet assay to investigate the protective properties of coffee. Coffee is one of the most popular and widely consumed beverages worldwide. 

Comet assay in 3D human skin models

 Researchers from across Europe and the USA have been working in collaboration to investigate inter- and intra-laboratory variation when performing the comet assay on reconstructed 3D human epidermal skin models.

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