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Mutagenesis Special Issue: The Comet Assay

 On January 1st 2015, the “Special Issue: The Comet Assay” of Mutagenesis was published. This edition was guest edited by comet assay expert Andrew Collins and features contributions from comet assay scientists from around the world.

Ocean Acidification and Artificial Seawater - The comet assay in an Arenicola marina study

 Ocean acidification, the change in pH and carbonate chemistry of the world’s oceans as a result of increasing atmospheric concentrations of carbon dioxide, is now broadly considered to represent a major threat to global marine biodiversity

Low molecular weight DNA diffusion (LMW) and comet assays

 Recently, investigators at Universität Ulm have been investigating the low molecular weight DNA diffusion assay (LMW assay) to measure cytotoxicity in comet assays. Here, the LMW assay has been proposed as an alternative, or a supplementation, to histopathology. 

Risk assessment: comet assay and Pig-a mutation assay used together

The OECD has recently released a test guideline for the in vivo comet assay and, prior to this release, researchers were interested in the performance of a combined comet assay/Pig-a gene mutation study.

OECD Guideline: Test No. 489, In Vivo Mammalian Alkaline Comet Assay

On 26 September 2014, the OECD Council adopted three new, five updated and one corrected OECD Test Guidelines for the testing of chemicals, one of these was Test No. 489, In Vivo Mammalian Alkaline Comet Assay.