Papers from 2009
Below are a number of refereed papers from 2009 in which Perceptive Instruments software is used for the comet assay. Applications of the systems include research and testing in nutrition, medicine, biomonitoring and genetic toxicology:
Cytotoxicity and oxidative DNA damage by nanoparticles in human intestinal Caco-2 cells
(2009) K. Gerloff et al, Nanotoxicology 3(4): 355-364
Delphinidin Modulates the DNA-Damaging Properties of Topoisomerase II Poisons
(2009) M. Esselen et al, Chem. Res. Toxicol. 22(3):554-564
Genotoxicity evaluation of locally produced dental porcelain – An in vitro study using the Ames and Comet assays
(2009) M. Noushad et al., Toxicol In Vitro. 23(6):1145-50
Nanoparticles can cause DNA damage across a cellular barrier
(2009) G. Bhabra et al., Nature Nanotech. (e-pub)
SiC nanoparticles cyto-and genotoxicity to Hep-G2 cells
(2009) S.Barillet et al J. Phys.: Conf Ser. 170 012016
β-Carotene metabolites enhance inflammation-induced oxidative DNA damage in lung epithelial cells
(2009) YG van Helden et al, Free Radic Biol Med.46(2):299-304
A class of DNA-binding peptides from wheat bud causes growth inhibition, G2 cell cycle arrest and apoptosis induction in HeLa cells
(2009) L. Mancinelli et al., Mol Cancer. 8(1):55
A Novel Liquid Multi-Phytonutrient Supplement Demonstrates DNA-Protective Effects
(2009) B. Baechler et al., Plant Foods Hum Nutr. 64(2):81-5
A unique program for cell death in xylem fibers of Populus stem
(2009) C.L. Courtois-Moreau et al, The Plant Journal 58(2):260-274
Alternariol acts as a topoisomerase poison, preferentially affecting the IIalpha isoform.
(2009) M. Fehr et al, Mol Nutr Food Res. 53(4):441-51
Antioxidant activities of major thyme ingredients and lack of (oxidative) DNA damage in V79 Chinese hamster lung fibroblast cells at low levels of carvacrol and thymol
(2009) U. Undeger et al, F. Chem. Toxicol. 47(8):2037-2043
Application of the comet assay and detection of DNA damage in haemocytes of medicinal leech affected by aluminium pollution: A case study
(2009) Z Mihaljević et al. Environmental Pollution 157(5):1565-1672
Assessment of DNA sensitivity in peripheral blood leukocytes after occupational exposure to microwave radiation: the alkaline comet assay and chromatid breakage assay
(2009) V.Garaj-Vrhovac & V.Oreščanin Cell Biol Toxicol 25(1):33–43
Assessment of genotoxic risks in Croatian health care workers occupationally exposed to cytotoxic drugs: A multi-biomarker approach
(2009) N. Kopjar et al, Int J Hyg Environ Health. 212(4):414-31
C-1027, A Radiomimetic Enediyne Anticancer Drug, Preferentially Targets Hypoxic Cells
(2009) T.A. Beerman et al, Cancer Research 69(2):593-598
Cellular uptake of platinum nanoparticles in human colon carcinoma cells and their impact on cellular redox systems and DNA integrity.
(2009) J. Pelka et al., Chem Res Toxicol. 22(4):649-59
Chronic exposure to MDMA (ecstasy) increases DNA damage in sperm and alters testes histopathology in male rats
(2009) M. Barenys et al., Toxicol Lett. 191(1):40-6
Chronic renal failure induces genetic instability in multiple organs of Wistar rats
(2009) D.A. Ribeiro et al, Eur J Clin Invest. 39(4):289-95
Citotoxicity status of electroplating wastewater prior/after neutralization/purification with alkaline solid residue of electric arc furnace dust
(2009) V. Orescanin et al, J Environ Sci Health A Tox Hazard Subst Environ Eng. 44(3):273-8
Combination of in vitro bioassays for the determination of cytotoxic and genotoxic potential of wastewater, surface water and drinking water samples
(2009) B. Zegura et al, Chemosphere 75(11):1453-1460
Comet Assay in Evaluating DNA Damage Associated With Ischaemia-Reperfusion Injury in Patients Undergoing Coronary Surgery
(2009) B. Karahalil et al., Arh Hig Rada Toksikol 60(3):307-315
Dietary zinc restriction and repletion affects DNA integrity in healthy men
(2009) Y. Song et al, Am J Clin Nutr. 90(2):321-8
Distinct effects of acute and chronic sleep loss on DNA damage in rats
(2009) M.L. Andersen et al, Prog Neuropsychopharmacol Biol Psychiatry. 33(3):562-7
DNA damage detected by the alkaline comet assay in the liver of mice after oral administration of tetrachloroethylene
(2009) H. Cederberg et al, Mutagenesis (e-pub)
DNA damage in horticultural farmers: a pilot study showing an association with organophosphate pesticide exposure
(2009) K.M. Atherton et al., Biomarkers. (e-pub)
DNA single- and double-strand breaks by alkaline- and immuno-comet assay in lymphocytes of workers exposed to styrene
(2009) M.E. Fracasso et al, Toxicology Letters 185(1):9-25
Drinking water quality: an in vitro approach for the assessment of cytotoxic and genotoxic load in water sampled along distribution system.
(2009) F. Maffei et al., Environ Int. 35(7):1053-61
Elevated metals compromise repair of oxidative DNA damage via the base excision repair pathway: implications of pathologic iron-overload in the brain on integrity of neuronal DNA
(2009) H. Li et al., J Neurochem. 110(6):1774-83
Enhancement of chemically induced reactive oxygen species production and DNA damage in human SH-SY5Y neuroblastoma cells by 872 MHz radiofrequency radiation
(2009) J. Luukkonen et al, Mutat. Res. 662(1-2):54-58
Epigenetic Reprogramming of IGF1 and Leptin Genes by Serum Deprivation in Multipotential Mesenchymal Stromal Cells
(2009) C. Sanchez et al, Stem Cells 27(2):375-382
Evaluation of DNA damage and lipoperoxidation of propofol in patients undergoing elective surgery
(2009) M.G. Braz et al., Eur J Anaesthesiol. 26(8):654-60.
Evaluation of genome damage and its relation to oxidative stress induced by glyphosate in human lymphocytes in vitro.
(2009) M. Mladinic et al, Environ Mol Mutagen. 50(9):800-7
Evaluation of radioprotective effects of propolis and its flavonoid constituents: in vitro study on human white blood cells
(2009) V Benkovic et al, Phyto. Res. 23(8):1159-1168
Evaluation of the cytogenetic damage induced by the organophosphorous insecticide acephate
(2009) D. Ozkan et al, Cytotechnology 59(2):73-80
Evaluation of the Cytogenetic Status of Human Lymphocytes After Exposure to a High Concentration of Bee Venom In Vitro
(2009) V. Garaj-Vrhova, G. Gajski, Arh Hig Rada Toksikol 60(1):27-34
Expression of stress-response ATF3 is mediated by Nrf2 in astrocytes
(2009) K.H. Kim et al., Nucl. Acids Res. (e-pub)
Fifty-gigahertz microwave exposure effect of radiations on rat brain.
(2009) K.K. Kesari & J. Behari, Appl Biochem Biotechnol. 158(1):126-39
Ganglioside GT1b protects human spermatozoa from hydrogen peroxide-induced DNA and membrane damage
(2009) M. Gavella et al, Int J Androl. (e-pub)
Genetic biomonitoring of an urban population exposed to mutagenic airborne pollutants
(2009) M.V. Coronas et al, Env. Int. 35(7):1023-1029
Genotoxic effects of anaesthetics in operating theatre personnel evaluated by the comet assay and micronucleus test
(2009) R.Rozgaj et al, Int. J. Hyg. Environ. Health 212(1):11-17
Genotoxic effects of neutrophils and hypochlorous acid
(2009) N. Gungor et al., Mutagenesis (e-pub)
Genotoxicity and cytotoxicity in multiple organs induced by titanium miniplates in Wistar rats
(2009) R. Piozzi et al, J Biomed Res A 88(2):342-7
Genotoxicity of cigarette smoking in maternal and newborn lymphocytes
(2009) K. R. Carvalho de Assis et al, Mutat Res. 679(1-2):72-8
Geostatistical analysis of DNA damage in oysters, Crassostrea virginica, in Lavaca Bay, Texas
(2009) W. Bissett et al, Ecotox. 18(1):1573-3017
Health risk assessment by measuring plasma malondialdehyde (MDA), urinary 8-hydroxydeoxyguanosine (8-OH-dG) and DNA strand breakage following metal exposure in foundry workers
(2009) H.H. Liu et al, J. Haz. Mat. 170(2-3):699-704
Homologous recombination but not nucleotide excision repair plays a pivotal role in tolerance of DNA-protein cross-links in mammalian cells.
(2009) T. Nakano et al., J Biol Chem. 284(40):27065-76
In vitro assessment of genotoxic effects of electric arc furnace dust on human lymphocytes using the alkaline comet assay.
(2009) V.Garaj-Vrhovac et al, J Environ Sci Health A Tox Hazard Subst Environ Eng. 44(3):279-87
In vitro cancer chemopreventive properties of polysaccharide extract from the brown alga, Sargassum latifolium
(2009) A. Gamal-Eldeen et al, Food Chem Toxicol. 47(6):1378-84
In vitro genotoxicity of root canal sealers
(2009) V. Brzovic et al, Int. Endod. J. 42(3):253-263
In vivo genotoxicity evaluation of a treated urban sewage sludge sample
(2009) M. de Lourdes Marzo Solano et al, Mutat. Res. 676(1-2):69-73
Induction of Macrophage Apoptosis by an Organochlorine Insecticide Acetofenate
(2009) M Zhao et al, Chem. Res. Toxicol. 22(3):504-510
Inhalation of formaldehyde does not induce systemic genotoxic effects in rats.
(2009) G. Speit et al., Mutat Res. 677(1-2):76-85
Interaction of ionizing radiation and ZRBA1, a mixed EGFR/DNA-targeting molecule.
(2009) M. Heravi et al., Anticancer Drugs. 20(8):659-67
Interactions of β-carotene and flavonoids on the secretion of pro-inflammatory mediators in an in vitro system
(2009) S.L. Yeh et al, Chem. Bio. Interactions 179(2-3):386-393
Low air levels of benzene: Correlation between biomarkers of exposure and genotoxic effects
(2009) M.E. Fracasso et al, Toxicology Letters (e-pub)
Measurement of oxidative DNA damage induced by mainstream cigarette smoke in cultured NCI-H292 human pulmonary carcinoma cells
(2009) F. Thorne et al, Mutat Res. 673(1):3-8
Molecular Signatures of N-nitroso Compounds in Caco-2 Cells: Implications for Colon Carcinogenesis
(2009) D.G.A.J. Hebels et al, Toxicol. Sci. 108(2):290-300
Neuroprotective effects of genistein and folic acid on apoptosis of rat cultured cortical neurons induced by β-amyloid 31-35
(2009) H.L. Yu et al, Br J Nutr. 102(5):655-62
Non-irradiated campherquinone induces DNA damage in human gingival fibroblasts
(2009) J. Volk et al., Dent Mater. 25(12):1556-63
Occupational exposure and DNA strand breakage of workers in bottom ash recovery and fly ash treatment plants
(2009) H.L. Chen et al., J Hazard Mater. 174(1-3):23-7
Oxidative stress and DNA damage in agricultural workers
(2009) G.E. Kisby et al, J Agromedicine 14(2):206-14
Partial hydrolysis enhances the inhibitory effects of konjac glucomannan from Amorphophallus konjac C. Koch on DNA damage induced by fecal water in Caco-2 cells
(2009) S.L. Yeh et al., Food Chemistry 119(2):614-618
Primary DNA Damage Assessed With the Comet Assay and Comparison to the Absorbed Dose of Diagnostic X-rays in Children
(2009) D. Milkovic et al, Int J Toxicol. 28(5):405-16.
Proliferative Activity In Vitro and DNA Repair Indicate that Adult Mouse and Human Sertoli Cells Are Not Terminally Differentiated, Quiescent Cells
(2009) E.A. Ahmed et al, Biol Reprod. 80(6):1084-91
Protective effect of linalool, myrcene and eucalyptol against t-butyl hydroperoxide induced genotoxicity in bacteria and cultured human cells
(2009) D. Mitic-Culafic et al, Food Chem. Toxicol. 47(1):260-266
Quartz-Containing Ceramic Dusts: In vitro screening of the cytotoxic, genotoxic and pro-inflammatory potential of 5 factory samples
(2009) C. Ziemann et al, J. Phys.: Conf. Ser 151 012022
RACK-1 overexpression protects against goniothalamin-induced cell death.
(2009) S.H. Inayat-Hussain et al., Toxicol Lett. 191(2-3):118-22
Radioprotective Effects of Honeybee Venom (Apis mellifera) Against 915-MHz Microwave Radiation–Induced DNA Damage in Wistar Rat Lymphocytes: In Vitro Study
(2009) G. Gajski, V.Garaj-Vrhovac Int. J. Toxicol. 28(2):88-98
Radioprotective Effects of Quercetin and Ethanolic Extract of Propolis in Gamma-Irradiated Mice
(2009) V. Benkovic et al., Arh Hig Rada Toksikol. 60(2):129-38
Repair of DNA damage induced by anthanthrene, a polycyclic aromatic hydrocarbon (PAH) without bay or fjord regions
(2009) C. Desler et al, Chem. Bio. Interactions 177(3):212-217
Responses of the European flounder Platichthys flesus to the chemical stress in estuaries: load of contaminants, gene expression, cellular impact and growth rate
(2009) E. Evrard et al., Biomarkers (e-pub)
Small-Molecule Drugs Mimicking DNA Damage: A New Strategy for Sensitizing Tumors to Radiotherapy
(2009) M. Quanz et al, Clin Cancer Res. 15(4):1308-16
Synergistic decrease of DNA single-strand break repair rates in mouse neural cells lacking both Tdp1 and aprataxin
(2009) S. El-Khamisy et al, DNA Repair 8(6):760-766
Synthesis, characterization and deepening in the comprehension of the biological action mechanisms of a new nickel complex with antiproliferative activity
(2009) A. Buschini et al, J. Inorg. Biochem. 103(5):666-677
The aldo-keto reductase AKR1C3 contributes to 7,12-dimethylbenz(a)anthracene-3,4-dihydrodiol mediated oxidative DNA damage in myeloid cells: Implications for leukemogenesis
(2009) J. Birtwistle et al, Mut. Res. 662(1-2):67-74
The emerging Fusarium toxin enniatin B: in-vitro studies on its genotoxic potential and cytotoxicity in V79 cells in relation to other mycotoxins
(2009) W. Follmann et al, Mycotox. Res. 25(1):11-19
The Fusarium toxin enniatin B exerts no genotoxic activity, but pronounced cytotoxicity in vitro
(2009) C. Behm et al, Mol Nutr Food Res. 53(4):423-30
Titanium dioxide nanoparticles induce oxidative stress and DNA-adduct formation but not DNA-breakage in human lung cells.
(2009) K Bhattacharya et al, Particle and Fibre Toxicology. 6(1):17
Transcript profiling and DNA damage in the European eel (Anguilla anguilla L.) exposed to 7,12-dimethylbenz[a]anthracene.
(2009) P. Nogueira et al., Aquat Toxicol. 94(2):123-30
Usage of the standard and modified comet assay in assessment of DNA damage in human lymphocytes after exposure to ionizing radiation
(2009) M.Mikloš, G.Gajski, V.Garaj-Vrhovac, Radiol Oncol 43(2):97-107